Public health in the 21st century is facing complex challenges that require social change with fundamentally new approaches to succeed. Public health practitioners can address these challenges by viewing their work in a larger social context, comprehending local and global issues in a deeper level, and collaborating with the community in a meaningful engagement. The successful implementation of health policies aimed at reducing health inequities and health inequalities lie in the ability of public health practitioners to integrate multiple disciplines and expertise, employ a systems thinking approach, and more importantly, collaborate with other health practitioners, policymakers, researchers, community members, and concerned stakeholders.